Angioedema is the end result of deep dermal, subcutaneous and/or mucosal swelling, and is potentially a life- threatening condition in cases where the pharynx or larynx is involved.Drug-induced angioedema has been reported to occur in response to a wide range of drugs and vaccines.Drug-induced angioedema, Candle Holder (Set of 3) like other cutaneous drug reactions, has been reported to be most frequently elicited by beta-lactam antibiotics and nonsteroidal anti-inflammatory drugs, although reliable data from epidemiologic studies are scarce.Recent reports suggested an increasing role of angiotensin-converting enzyme inhibitors (ACEIs) in the causation Tonie copyright Case of life- threatening angioedema.ACEI-related angioedema is never accompanied by urticaria and occurs via a kinin- dependent mechanism.
ACEI-related angioedema not only can start years after beginning the treatment, but it can then recur irregularly while under that treatment.Furthermore, allergy tests are unreliable for the diagnosis of ACEI-related angioedema, and so the relationship between angioedema and ACEIs is often missed and consequently quite underestimated.Accordingly, better understanding of the kinin-dependent mechanism, which is particular to angioedema, is necessary for the appropriate management of drug-induced angioedema.